Clinical Update – Upper GI bleeding and gastroprotection in very high-risk patients

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PPI therapy should be carefully tailored to the individual needs of patients at high risk of peptic ulcers and gastrointestinal bleeding

You will learn:
 Protein pump inhibitors (PPI’s) are invaluable and very effective agents used for the management of gastrointestinal (GI) acid-related disorders1
While PPI’s are the cornerstone of gastroesophageal reflux disease (GERD) treatment, 40% of patients do not derive full symptom relief with these agents2
Better results can be achieved by selecting a particular PPI for each GERD-confirmed patient based on that PPI’s pharmacokinetic, pharmacogenomic and antioxidant actions 
New data showing that some PPIs have potent antioxidant properties create an opportunity to provide a dual-action protective role in very high-risk patients
Upper GI bleeding is a major health problem and the definition of groups at high risk for developing peptic ulcer complications helps to prioritise the provision of PPI therapy


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