
Therapeutic and recreational codeine misuse raises concerns about accessibility and pain relief effectivity of different doses. Recognising signs of abuse and understanding where codeine is best utilised underpin best practice.

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- Question 1 of 15
1. Question
1. Misuse/abuse of codeine outside of acceptable medical practice may include:
- Question 2 of 15
2. Question
2. Of ingested codeine, what proportion is metabolised by the CYP2D6 pathway?
- Question 3 of 15
3. Question
3. In South Africa, a prescription is required to sell codeine (<20mg) combination products containing paracetamol, ibuprofen or aspirin.
- Question 4 of 15
4. Question
4. Which of the listed international agencies recommend against the use of codeine for the treatment of pain and cough in children (<12 years)?
- Question 5 of 15
5. Question
5. WHO recommendations for analgesia in adult patients include the use of codeine as an initial opioid treatment with a pain score of:
- Question 6 of 15
6. Question
6. Efficacy evaluation of low-dose codeine (<30mg) combination medicines from randomised controlled trial data shows:
- Question 7 of 15
7. Question
7. To achieve at least 50% maximum pain relief over 4-6 hours using 60mg codeine, Cochrane review data show an NNT of:
- Question 8 of 15
8. Question
8. NICE guidance for effective non-opioid lower back pain relief in adults includes the use of:
- Question 9 of 15
9. Question
9. Which statement is false? NICE guidance for effective non-opioid pain relief from sprains and strains in adults includes the use of:
- Question 10 of 15
10. Question
10. 2014 data on South African drug use recorded what percentage of drug-dependent admissions as related to codeine abuse?
- Question 11 of 15
11. Question
11. Therapeutic codeine dependency can be described as:
- Question 12 of 15
12. Question
12. Treatment of therapeutic codeine dependency at low level of use is based on:
- Question 13 of 15
13. Question
13. Consider referral to specialist services in the case of moderate or high-level codeine use, as this level of opiate withdrawal presents specific challenges requiring hospitalisation or in-facility care.
- Question 14 of 15
14. Question
14. Which statement is false?
- Question 15 of 15
15. Question
15. Mental health issues are commonly associated with codeine misuse.
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