Module 1: Vaccine-Preventable Pneumonia Series: Not so sweet! Capsular polysaccharide type 3 and pneumococcal disease

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Vaccine-Preventable Pneumonia Series: Which Streptococci are causing pneumonia deaths in South Africa? Presenting the evidence to guide the clinician's selection of preventative vaccines for children and older adults

Learning objectives

You will learn:

  • Insights regarding the variable pathogenesis of different Streptococcus pneumoniae serotypes (STs) and the important role of capsule polysaccharide in virulence
  • An understanding of why pneumococcal vaccine strategies are influenced by ongoing and sustained monitoring of STs associated with invasive pneumococcal disease (IPD) and mortality
  • An awareness of IPD STs associated with pneumococcal vaccine breakthrough and unique features of ST3 that enable vaccine escape
  • The impact of different pneumococcal conjugate vaccines (PCVs) as routine childhood vaccinations in South Africa
  • Clinical evidence demonstrating the safety and efficacy of PCV15, especially in relation to ST3.

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