Questionnaire

1. SEER programme data demonstrate significantly worse five-year relative survival rates at diagnosis when the CRC is:

2. It has been determined after 24 years follow-up that one colonoscopy reduces CRC mortality by 68%.

3. To reduce CRC mortality and morbidity and to entirely prevent the development of CRC, the American Cancer Society recommends colonoscopy screening in adults aged:

4. A radiological technique that is used for staging regional CRC, including lymph nodes, is:

5. A CRC carcinogenesis pathway that is associated with genetic instability due to a deficient DNA MMR system is:

6. The most common aetiology of CRC is:

7. The four CMS of CRC each have unique:

8. The most commonly occurring molecular subtype of CRC is:

A worse relapse-free survival across CRC stages II and III is observed in the subtype:

In metastatic disease, patients with CRC CMS1 tumours demonstrate superior survival after relapse compared to the other three CMS categories.

Negative biomarkers for anti-EGFR therapies in CMS2 CRC tumours are:

For the treatment of KRAS mutant metastatic CRC, anti-VEGF therapies that are commonly used in South Africa include:

PFS and OS are almost halved in cetuximab-treated patients with metastatic CRC that harbours:

For the treatment of MSI-H metastatic CRC, pembrolizumab targets:

Essential elements of post-operative care and recovery after CRC surgery includes: