Questionnaire

1. Despite the success of the national PCV programme, IPD remains a very important cause of hospitalisations and deaths in young children, people who are immunosuppressed, and older adults.

2. Primary infections that can be caused by the spread of invasive S. pneumoniae STs from the nasopharyngeal mucosa to other sites of the respiratory tract include:

3. The percentage of children in South Africa who have nasopharyngeal colonisation with pneumococcus by the age of six weeks is:

4. An important role of respiratory viruses in pneumococcal disease is a heightening of susceptibility to:

5. Most cases of pneumococcal pneumonia present secondary to bacteraemia, rather than being a primary infection.

6. Polysaccharide-protein conjugate vaccines:

7. Most cases of IPD in children <5 years are caused by STs:

8. The most commonly occurring non-vaccine IPD STs in age <5 years are:

9. The PCV15 phase 3 clinical programme has demonstrated safety and efficacy when administered:

10. The PNEU-WAY PED trial comparing PCV15 to PCV13 in children aged 6-17 years and living with HIV found, at Day 30 after administration, that IgG GMCs and OPA GMTs were: